Each milliliter of FLUMINE Injectable Solution contains flunixin meglumine equivalent to 50 mg flunixin. Flunixin meglumine is a nonsteroidal anti-inflammatory drug not related to the corticosteroids, but pharmacologically related to phenylbutazone, aspirin, indomethacin or dipyrone, and the other NSAID (nonsteroidal anti-inflammatory) agents. It also has analgesic (pain-relieving) and antipyretic (fever-reducing) activity, which is secondary to its anti-inflammatory effect. The drug acts directly at the level of the tissues, not via a nervous system action. It acts primarily on inflamed tissues and is used for muscle or bone/joint diseases and in the treatment of colic pain.
Horses: FLUMINE Injectable Solution is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse.
Cattle: FLUMINE Injectable Solution is indicated for the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis. FLUMINE Injectable Solution is also indicated for the control of inflammation in endotoxemia.
ADMINISTRATION AND DOSAGE:
The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Intravenous administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur.
The recommended dose for cattle for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia is 1.1 to 2.2 mg/kg (0.5 to 1 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight. Avoid rapid intravenous administration of the drug.
The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb: 2 mL per 100 lbs) of body weight given once by intravenous administration.