For use as an aid in the treatment of coagulation disorders associated with hypoprothrombinemia due to vitamin K deficiency or interference with vitamin K activity, or anticoagulant induced hypoprothrombinemia such as sweet clover disease in cattle and poisoning with anticoagulant rodenticides in dogs.
DOSAGE AND ADMINISTRATION:
Cattle, Horses, Calves, Swine, Sheep and Goat:
Acute hypoprothrombinemia (with hemorrhage): 0.5 – 2.5 mg / kg of body weight, by slow intravenous injection at a rate not to exceed 10 mg / minute in mature animals and 5 mg / minute in newborn and very young animals.
Nonacute hypoprothrombinemia: Intramuscularly or subcutaneously 0.25 – 2.5 mg / kg of body weight.
For intravenous administration, dilute with preservative free 5% dextrose, 0.9% sodium chloride injection or 5% dextrose in 0.9% sodium chloride injection. Do not use any other diluents.
Administration should be started immediately after mixture with the diluents. Avoid rapid infusion. Discard unused portion of the mixture. Determine the frequency and amount of subsequent doses by monitoring prothrombin time response and clinical condition.